Australian Law Essay Example | Topics and Well Written Essays - 750 words

Australian Law - Essay Example â€Å"Decisions of the High Court are binding on all other courts throughout Australia† (High Court of Australia 2010: The High Court of Australia is the uppermost Court in the judicial system of Australia, the Court of "last resort", in the judicial system of final appeal. It has its origins in the Australian Constitution, Section 71 of which affirms: â€Å"The judicial power of the Commonwealth shall be vested in a Federal Supreme Court, to be called the High Court of Australia, and in such other federal courts as Parliament creates, and in such other courts as it invests with federal jurisdiction† (The High Court of Australia n.d: 1). The High Court shall comprise a Chief Justice and also a lot of other Judges, not below two, as the Parliament has laid down. The fundamental functions of the High Court are to construe and support the Constitution, to construe Federal law and to attend to cases referred from other Courts. Therefore, it is the purpose of this essay to d iscuss why a decision of the High Court on the constitutionality of a Statute will be seen by the Government as a further serious setback to its legislative reform plan than a judgment by a Judge of a State Supreme Court in understanding the meaning of an important provision in the statute, in a way contrary to the Government’s goal.... of this essay to discuss why a decision of the High Court on the constitutionality of a Statute will be seen by the Government as a further serious setback to its legislative reform plan than a judgment by a Judge of a State Supreme Court in understanding the meaning of an important provision in the statute, in a way contrary to the Government’s goal. The Australian Constitution states that the power to create laws is vested in the Parliament. At the same time, the power to understand laws and to judge whether they are relevant in individual cases is vested in the High Court and other Central Courts. Actually, one of the important functions of the High Court is to interpret the Constitution. For instance, the Australian High Court can rule a law to be illegal which is beyond the authority of Parliament to enact and so of no effect. Such a condition would be seen by the Government as an obstruction. The Australian Constitution founds the Federal Government by providing for the Parliament, the Judiciary and the Executive, that is identified as the three pillars of governance or as the policy of â€Å"separation of powers† (Clark 2009: 972). Parliamentary Government means that the Executive Government comes from in the Parliament. Accountable Government means that the Executive Government is accountable to the Parliament. The rule of â€Å"separation of powers† is to prevent an oppressive government. The â€Å"three branches of government† constituted by the Legislature, Judiciary and Executive, work as checks and balances on each other (About Parliament. n.d:1). The Judiciary is â€Å"independent† of the other two arms of Government (1). That independence is one of the main critical safeguards of the democratic system of the country. The Executive is the managerial part of

Strategic Management Essay Example | Topics and Well Written Essays - 1000 words - 6

Strategic Management - Essay Example Primark has been a retailing giant in the fashion industry that has over a few years been successful. Some of its strategies have over the years included effective marketing to specific targets across Europe. Primark’s target market is mostly the fashion sensitive age group which is basically people with the age below thirty five years of age. They also deal mostly with brand names that are minor, which translates to cheap quality fashionable trends. They have maintained their market by providing the same product of the same quality at a lower price than their competitor provide. This accompanied with the effective management of response and delivery mechanisms has ensured that Primark has maintained its competitive and reliability position in the European market. Their computerised warehouse controls and an effective efficient distribution networks has made sure that Primark stays top notch in customer satisfaction. With the current technological capability, social life has b een incorporated with the business aspect of running things. Companies have been compelled to adapt social media and the use of the internet to provide their services. Marketing and advertising have been forced to tap into the high usage of internet to make a large profit. With just under three billion people using the internet and over two billion people using smart phones, companies have resolved to a paradigm shifts. Some retail and distributing stores have moved from slightly depending on the internet to full dependence of the internet for all their services. Companies like Amazon and eBay who are also giant retailers have completely depended on online shoppers successfully for their sales. Primark has been reluctant to adapt to this marketing and sales strategies but has just kept the traditional walk in stores. This habit is however facing a challenge as more people change their shopping habit coupled with the various technological products that arise in the market. With Prima rk’s main target being people who are below thirty-five years of age, they are bound to adjust and shift into providing online shopping solutions for their clients. This is because it is estimated that the highest number of internet users are people who are below the age of thirty five years. This brings Primark head to head in confrontation and demand from its customers. With the global penetration of internet use, coupled with the increase in the use of mobile devices especially smart phones also creates the necessity to Primark of adoption an online shop. The demand in the usage of these solutions provides a huge market in the retail sector. Another factor that might make it inevitable for Primark to adopt the online retail shop is the use of social media marketing and internet marketing. Over one, half of Europe’s population has one or two active social media accounts. The usage of mobile phones and tablets has been very addictive and convenient at the same time. A large number of people rarely get the time to walk around, let alone spend time with their families. Online jobs and jobs that demand regular travelling or jobs which have squeezed time schedules create least chances for shopping to the affected people. This drives away all the interested clients that might have purchased the said products. Providing such clients with an alternative shopping model enables them to purchase the products online at any time. This not only stops the retailer from losing

CATEGORIES OF DISABILITIES Assignment Example | Topics and Well Written Essays - 1250 words

CATEGORIES OF DISABILITIES - Assignment Example s for Disease Control and Prevention (CDC), the frequency of autism in the United States is 1 out of every 68 children (Bakken, Obiakor, and Rotatori 37). This translates into 1 out of every 42 boys and 1 out of every in 189 girls. According to IDEA, deaf-blindness means simultaneous visual and hearing handicaps, the mix of which results in such serious communication and other academic and growth needs that the affected child cannot fit in special academic programs meant for children with visual or hearing handicaps (Mamlin 35). IDEA defines deafness as a hearing handicap so serious that a child is limited in interpreting linguistic information via hearing, with or without sound intensification, which negatively affects the academic ability of a child (Doyle 107). This is a condition marked by the following attributes: a learning problem that cannot be rationalized by sensory, medical, or intellectual issues; an inability to establish or sustain good interpersonal relationships with teachers and other classmates; a general ubiquitous feeling o depression or melancholy; inappropriate emotions or types of conduct in normal situations; and a habit of developing physical traits or phobias related to personal or academic problems (Colker 47). These attributes are displayed over a long period and to a considerable extent that detrimentally affects the academic performance of a child. This definition includes schizophrenia but is inapplicable to socially maladjusted children, unless it is verified that they are emotionally disturbed. 8.3 million children (14.5 percent) between the ages of four and seventeen have parents who have consulted healthcare providers or academic personnel about their emotional or behavioral challenges (Colker 109). Doctors have prescribed drugs for these problems for around 2.9 million. This disability is defined as a handicap in hearing, whether intermittent or permanent, that has a regressive effect on the educational ability of a child,

Sub-human working conditions in Qatar Research Paper

Sub-human working conditions in Qatar - Research Paper Example The world cup is the most widely viewed sports event in the world and requires a lot of preparation by host countries to be in a position to stage the world cup owing to the high number of spectators, reporters, business people, and players who come to the host country for the world cup. Qatar has been making these preparations since 2010 when it was selected to host the 2022 world cup but there are rampant cases of inhuman working conditions for workers making preparations in stadia and other facilities in the country. It is from this understanding that this study aims at enumerating why FIFA and football associations should force Qatar to stop the "sub-human" working conditions. Workers involved in infrastructure development for the 2022 world cup are exposed to harsh working conditions including withheld payments, working in 122-degree heat for a long time with no provision of food or water, and their passports were confiscated to ensure they do not leave the country (Kwok & Wallis, 2008). Workers cannot be able to help their families and pay obligations for their jobs to recruitment agencies with 36% interest payment rates affecting their families and their person negatively (Manfred, 2014). For a country that will host the world cup, these conditions are unacceptable owing to the high benefits to be received by the country and the high following that the world cup has globally. This will taint the name of the world cup and FIFA, if the football associations and FIFA do not take the steps to correct the situation in Qatar in terms of working conditions. The intolerable working conditions in Qatar have led to the death of at least 1200 workers in different infrastructural development in preparation for the world cup with 400 of them from Nepal, 00 from India, and others from Philippines, Pakistan, Kenya, and other parts of the world. This is in accordance to a report by The International Trade Union Confederation (Manfred,

School Choice †An Educational Custom Fit Essay Example for Free

School Choice – An Educational Custom Fit Essay Imagine if only one size of pants were sold in stores and government regulations wouldn’t allow any other size to be made available to consumers. This may sound crazy but it’s much like what’s happening with the education of our nation’s children. As Americans we enjoy a wide range of personal choice, and thankfully it includes our ability to select the pants that fit us best. But think for a moment about traditional public education. For decades the public school system has offered a one size fits all approach to educating our nation’s children. As we approached the 21st century, the public school system began to show its age. More and more children began to fall behind in a rapidly changing environment marked by the introduction of personal computers and later the internet. Sensing a need for change, many people began to push for new educational models that would keep up with the times. This marked the beginning of the school choice movement. Both charter schools and school voucher programs are collectively referred to as â€Å"school choice† initiatives, in that they allow parents freedom to choose individualized education options for their children that are outside of the traditional â€Å"one size fits all’ public school system. A school voucher program provides parents with certificates that are used to pay for education at a school of their choice, rather than the public school to which they are assigned. Charter schools on the other hand are publicly funded schools that have been freed from inefficient public school system rules and regulations in exchange for accountability to produce positive, measurable results. These agreed to results are set forth in each school’s.

Penicillins Structure and Function

Penicillins Structure and Function Rachael Sim Hwee Ling A Molecule that Shapes the World – C16H18N2O4S The discovery of penicillin has revolutionized the world of medicine and saved millions of lives. Penicillin is a group of antibiotics derived from Penicillium fungi  [1]. Antibiotics are specific substances derived from living organisms that can inhibit the life processes of other organisms  [2]. Penicillin is effective against a range of bacteria such as staphylococciand streptococci and bacteria causing diseases like meningitis and gonorrhea  [3]. Unlike sulfanilamide which is toxic to the kidney, penicillin has no harsh effects. It is non-irritating and can be applied to tissues directly  [4]. During World War II, the administration of penicillin to the wounded soldiers greatly reduced their chanceS of injury infection and raised their survival chances in the interim time between the wounding and surgery (14 hours for the Allied Forces), thus dramatically reducing the need for amputations and the death toll from infected wounds  [5]. Today, penicillin is still commonly used to treat conditions. Penicillin is often prescribed after dental surgery to prevent infections  [6]. The diseases and infections mentioned above are caused by bacteria. Almost all bacteria have cell walls made up of peptidoglycan, a rigid but elastic structure, that protects the underlying protoplast from mechanical damage and prevent it from bursting under osmotic pressure. Peptidoglycan is made up of long polysaccharide chains that are cross-linked via flexible peptide bridges  [7]. The synthesis of bacterial cell wall is catalyzed by the enzyme transpeptidase. Such synthesis is essential to the growth, cellular reproduction and maintaining the structure of bacteria. In 1965, Tipper and Strominger hypothesized that penicillin kills bacteria by blocking the action of the transpeptidase that catalyzes the last step of synthesis which involves the cross-linking of different peptidoglycan chains, thus inhibiting the synthesis of the cell wall  [8]. Water then enters the cell causing it to swell and explode. This essay will discuss how penicillin’s shape, structure, instability enable it to inhibit the action of transpeptidase, examine the science behind penicillin’s reaction, how the structure and size influence its effectiveness and the significance of the lack of symmetry. Penicillin structure consists of a thiazolidine ring fused to a ÃŽ ²-lactum ring to which a variable R group is attached by a peptide bond. (Fig 1) Penicillin G (Fig 2), which has a benzyl side-chain, is often regarded as the prototype of the class as it is one of the first-generation penicillin that can be obtained directly from the fungi. It is the most potent of the class against susceptible gram-positive bacteria and is still widely used.[9] Penicillin G is only effective against gram-positive bacteria in which the transpeptidases are directly accessible. Fig 1: General Penicillin molecule with R side chain, 3 chiral centres (*) and a ÃŽ ²-lactum ring (blue) Fig 2: Natural penicillin-G where R = benzyl group Fig 3: D-Alanyl-D-alanine which closely resembles penicillin (In D-amino acid, with the H atom pointing up and looking down from the H atom and moving anti-CW, the amino acid has the order COOH, R, NH2) One explanation about the mechanism of action of penicillin is that it mimics the shape and structure of the D-alanine-D-alanine termini of bacterial peptidoglycan (the usual substrate) and is thus recognized by transpeptidases  [10]. The transpeptidase enzyme reacts preferentially and binds irreversibly with penicillin. The penicilloyl-enzyme formed is stable and does not react any further  [11]. The free COOH group present mimics that of terminal carboxyl of D-alanine-D-alanine and is needed for penicillin to bind at the active site  [12]. The similarities in their molecular structures can be clearly observed in Fig1 and Fig3. Furthermore, as penicillin lacks symmetry, its mirror images are non-super-imposable. In order for penicillin to be biologically active, the 3 chiral centres in penicillin must be in the configuration in Fig1  [13]. As penicillin’s activity is stereo-dependent, penicillin synthesized must be enantiopure and the arrangement of the groups relativ e to one another should resemble that of D-alanine-D-alanine. This also explains penicillin non-toxicity. D-alanine only occurs in the cell wall of bacteria and all the proteins within our body are built up from L-amino acids. Hence, penicillin kills bacteria but will not adversely affect humans.  [14] Another explanation also relates to the structure of penicillin and the instability of the cyclic amide in ÃŽ ²-lactum ring which is fused to the thiazolidine ring. Research by Strominger has shown that the activity of penicillin is due to the inherent strain of the four-membered ring or to the reduced amide resonance  [15]. In the four-membered ring, the C and N atoms are forced to have a bond angle of approximately 90 ° which is far below the preferred bond angle for singly-bonded sp3 hybridised carbon and nitrogen atoms (109.5 °) and doubly-bonded sp2 hybridised carbon atom (120 °). This put the small ring under great ring strain which is further aggravated by the five-membered thiazolidine ring fused with it. X-ray crystallography has also showed that the two fused rings and the amide bond is non-planar. This leads to a loss of resonance stabilization normally found in these amide bonds  [16]. These make the amide group more reactive. Penicillin acylates the enzyme and form an open chain compound to relieve the strain. Furthermore, it is hypothesized that the –COOH group in penicillin’s structure contributes to penicillin’s widely varying acylating ability and its ability to travel through bodily fluids unaltered and only target transpeptidase in bacteria. Experimental data obtained from inelastic neutrons and quantum chemical theory suggests that the activity of penicillin is pH dependent  [17]. Under physiological conditions (pH = 7.4), penicillin’s -COOH group is deprotonated. As COO and the lone pair of electrons of N are on the same face of the molecule, the COO will repel the lone pair of electrons on the N atom. This shortens the amide bond, increases its strength and decrease the acylating power of the lactam ring  [18]. When near the active site of transpeptidase, COO group is protonated and the ÃŽ ²-lactum amide bond regains its strong acylating power  [19]. The 2 CH3 group is also important for activation as research has found no activity for penicillin analogues with these groups removed.  [20] At the active site, the science of reaction is as follows. The nucleophilic –OH group of the serine residue attacks and opens the ring. A covalent bond is formed between the serine on the enzyme and the penicillin molecule  [21], irreversibly inhibiting the normal function of the enzyme and kills the bacterial cell. The R group in the penicillin structure determines the effectiveness of the penicillin drug. Penicillin-G cannot be consumed orally as gastric acid will catalyze the hydrolysis of the highly unstable ÃŽ ²-lactum ring, destroying its antibiotic properties. The ÃŽ ²-lactum ring is also susceptible to attack by O atom of the neighboring carbonyl group. To prevent this, we can choose an electron withdrawing R group to decrease the nucleophilicity of the carbonyl oxygen on the acyl side chain to reduce the self destructive mechanism[22]. To avoid degradation by penicillinase enzyme, we can choose a bulky R group as a steric shield. The small size of penicillin molecules increases their potency as it enables them to penetrate the entire depth of the cell wall. In conclusion, penicillin-G is a molecule that was cleverly designed molecule by nature. All features in its structure – its bicyclic system, unstable ÃŽ ²-lactum ring, COOH group, stereochemistry and size is essential and influence its effectiveness. They enable penicillin to irreversibly react with transpeptidases, kill harmful bacteria and by doing so, save lives and shape the world. [1] penicillin. (n.d.)The American Heritage ® Medical Dictionary. (2007). Retrieved January 31 2015 fromhttp://medical dictionary.thefreedictionary.com/penicillin [2] antibiotic. (n.d.)The American Heritage ® Medical Dictionary. (2007). Retrieved January 31 2015 fromhttp://medical-dictionary.thefreedictionary.com/antibiotic [3] penicillin. (n.d.)Dorlands Medical Dictionary for Health Consumers. (2007). Retrieved January 31 2015 fromhttp://medical-dictionary.thefreedictionary.com/penicillin [4] Fleming, A. (1929). On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae.British journal of experimental pathology,10(3), 226. Couteur, P., Burreson, J. (2004). Wonder Drugs. InNapoleons buttons: 17 molecules that changed history. Jeremy P. Tarcher/Penguin: New York. [5] Medicine and World War Two. (2014, January 1). Retrieved January 31, 2015, from http://www.historylearningsite.co.uk/medicine_and_world_war_two.htm [6] Ross-Flanigan, Nancy; Uretsky, Samuel. Penicillins.Gale Encyclopedia of Childrens Health: Infancy through Adolescence. 2006. Retrieved January 31, 2015 from Encyclopedia.com:http://www.encyclopedia.com/doc/1G2-3447200431.html [7] Graumann, P. (2007).Bacillus: Cellular and molecular biology(p. 333). Norfolk: Caister Academic Press. [8] Tipper, D., Strominger, J. (1965.). Mechanism Of Action Of Penicillins: A Proposal Based On Their Structural Similarity To Acyl-D-alanyl-D-alanine.Proceedings of the National Academy of Sciences,1133-1141 [9] Penicillins. (n.d.). Retrieved January 31, 2015, from http://www.emedexpert.com/compare/penicillins.shtml#4 [10]Tipper, D., Strominger, J. (1965.). Mechanism Of Action Of Penicillins: A Proposal Based On Their Structural Similarity To Acyl-D-alanyl-D-alanine.Proceedings of the National Academy of Sciences,1133-1141. [11] Berg, J., Tymoczko, J. (2002). Enzymes: Basic Concepts and Kinetics. InBiochemistry(5th ed.). New York: W.H. Freeman. [12] Tipper, D., Strominger, J. (1965.). Mechanism Of Action Of Penicillins: A Proposal Based On Their Structural Similarity To Acyl-D-alanyl-D-alanine.Proceedings of the National Academy of Sciences,1133-1141. [13] Bentley, R. (2004). The Molecular Structure of Penicillin.Journal of Chemical Education,1462-1462. [14] Otter, C. (2008). Chemical ideas (3ed. ed.). Oxford [u.a.: Heinemann Educational. [15] Strominger, J.L. (1967) . Enzymatic reactions in bacterial cell wall synthesis sensitive to penicillins, cephalosprins and other antibacterial agents. Antibiotics, 705–713 [16] J. C. Sheeman, The enchanted Ring: The Untold Story of Penicillin, The MIT Press, Cambridge, Massachusetts, 1982 J. R. Johnson, R. B. Woodward and R. Robinson, in The Chemistry of Penicillin, ed. H. T. Clarke, J. R. Johnson and R. Robinson, Princeton University Press: Princeton, New Jersey, 1949, ch. 15, pp. 443–449. [17],18,19 Mucsi, Z.; Chass, G.A.; Abranyi-Balogh, P.; Jozart, B.; Fang, D.-C.; Ramirez-Cuesta, A.J.; Viskolcz, B.; Csizmadia, I.G. Penicillin’s catalytic mechanism revealed by inelastic neutrons and quantum chemical theory. Phys. Chem. Chem. Phys. 2013, 15, 20447–20455 [18] [19] [20] S. Wolfe, J. C. Godfrey, C. T. Holdrege and Y. G. Perron, J. Am. Chem. Soc., 1963, 85, 643 ; S. Wolfe, J. C. Godfrey, C. T. Holdrege and Y. G. Perron, Can. J. Chem., 1968, 46, 2549.; J. Hoogmartens, P. J. Claes and H. Vanderhaeghe, J. Med. Chem., 1974, 17, 389;T. K. Vasudevan and V. S. R. Rao, Int. J. Biol. Macromol., 1982, 4, 219. [21] Yocum, R., Strominger, J., Rasmussen, J., Waxman, D. (1979). Mechanism of Penicillin Action: Penicillin and Substrate Bind Covalently to the Same Active Site Serine in Two Bacterial D-alanine Carboxypeptidases.Proceedings of the National Academy of Sciences,2730-2734. [22] Proctor, P., Gensmantel, N., Page, M. (1982). The chemical reactivity of penicillins and other ?-lactam antibiotics.Journal of the Chemical Society, Perkin Transactions 2,1185-1185.

The Power of Words Essay -- Language

"The picture he had of the city was reduced to what she said of it, and finally it was her speech alone that could call up and protect that picture. †©He †©came †©to †©the†© conclusion †©that, †©once†© abandoned †©by†© words, †©the †©city†© would †©fall †©into†© ruins.† — Abdekelkebir †©Khatibi, †©Love†© in †©Two†© Languages Words are very powerful things, they are not simply just letters written on a sheet of paper; they can inspire, motivate, and evoke certain emotions. Think of your favorite songs and realize that the lyrics can bring joy, happiness, sadness, depression, loneliness, longing, or any emotion imaginable to others based on their own personal experiences. Dave Matthews’ song lyrics for â€Å"Funny The Way It Is† are able to capture this phenomenon when he says, â€Å"Funny the way it is, Whether right or wrong, Somebody's heart is broken, And it becomes your favorite song† (â€Å"Pandora† np). Examples of the pure power of words have been shown throughout mankind’s history. Many great leaders such as Jesus Christ, Martin Luther King Jr., Abraham Lincoln, and even our current president, President Obama, used words to influence, motivate, and encourage their followers in positive ways. Authors in literature have recognized this trend and use powerful sayi ngs or words to intensify their plot and to evoke specific emotions from their audience. â€Å"Timshel† or â€Å"thou mayest† was a reoccurring word in John Steinbeck’s fictional novel East of Eden, their was a struggle or contemplation of the exact translation that was parallel to the theme of good vs. evil found throughout the three generations of brothers (Steinbeck np). This one word meant redemption, forgiveness, and liberation all at once. Another example of the power of words in literature is in Co... ...om/kiterun.htm>. Hosseini, Khaled. The Kite Runner. New York City : Penguin Group, 2003. "Martin Luther King's 'I have a dream' Speech". Syque. June 6, 2010 . McCarthy, Cormac. The Road. New York City : Alfred A. Knopf, 2006. "Pandora". Pandora Media Inc.. June 6, 2010 . SparkNotes Editors. â€Å"SparkNote on East of Eden.† SparkNotes.com. SparkNotes LLC. 2003. WAccessed: 2 Jun. 2010. SparkNotes Editors. â€Å"SparkNote on The Kite Runner.† SparkNotes.com. SparkNotes LLC. 2010. Accessed: 2 Jun. 2010. Steinbeck, John. East of Eden. New York City : Penguin Group,1952. "The Road". Wikipedia. June 6, 2010 . "The Story of Cain and Abel". DLTK's Growing Together. June 6, 2010 .